解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and di...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000215581
更新日期:2009-01-01 00:00:00
abstract::The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258504
更新日期:2009-01-01 00:00:00
abstract::Although the incidence of gastric cancer has been declining in Western countries, it is still a major health problem and a leading cause of cancer mortality. Surgery is the mainstay of treatment for gastric adenocarcinoma. However, even among patients undergoing gastrectomy with curative intent, 5-year survival rates ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258494
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The phosphatidylinositol 3-kinase (PI3K) pathway plays a critical role in ovarian cancer cell survival and proliferation. The aim of this study was to determine whether the suppression of the PI3K catalytic subunit p110alphainhibits the growth of ovarian cancer cells in vitro and in vivo. METHODS:The short h...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000218201
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Whether recurrence after surgery and primary metastatic pancreatic cancer should be included in the same category when conducting gemcitabine-based clinical trials remains controversial. OBJECTIVE:To clarify the outcomes of recurrent and metastatic pancreatic cancers. METHODS:326 patients who received gemc...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000236022
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Bevacizumab (Avastin) significantly improves overall survival (OS) and progression-free survival (PFS) when combined with first-line irinotecan (IFL) plus bolus 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic colorectal cancer (CRC). This open-label, phase IV trial evaluated the efficac...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000229787
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000209963
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC. METHODS:Ap...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000201572
更新日期:2009-01-01 00:00:00
abstract::Nicotinamide, the amide derivative of vitamin B(3), cooperates with retinoic acid (RA), a form of vitamin A, and 1,25-dihydroxyvitamin D(3) (D3), to regulate cell differentiation and proliferation of human myeloblastic leukemia cells. In human myeloblastic leukemia cells, RA or D3 are known to cause MAPK signaling lea...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000188664
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Cancer patients have a higher risk for thrombosis that is usually related to advanced stage and poor prognosis. This study aimed to identify the clinical picture and outcome of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients with pulmonary embolism (PE). PATIENTS AND METHODS:Fr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000229503
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000236048
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The microenvironment of cancer plays a critical role in its progression. However, the molecular features of cancer-associated fibroblasts (CAFs) are less well understood than those of cancer cells. We investigated the clinicopathological significance of podoplanin expression in stromal fibroblasts in patients...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226112
更新日期:2009-01-01 00:00:00
abstract::Surgical resection, transarterial chemoembolization, percutaneous ethanol injection therapy, radiofrequency ablation, and orthotopic liver transplantation are generally accepted treatment modalities in hepatocellular carcinoma, but there has been no standard therapy for patients at the advanced stage. Several combinat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000173432
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients. METHODS:Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151369
更新日期:2008-01-01 00:00:00
abstract::Primary and secondary prevention of hepatocellular carcinoma (HCC) which has become endemic worldwide in recent years are the most important issues in reducing mortality of HCC patients. Among several compounds previously reported for secondary prevention, treatment with interferon (IFN) is widely applied and shows en...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000173422
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC). METHODS:Nine previously reported predictive markers for liver metastasis and/or prognosis (COX-2, dysadherin, E-cadherin, beta-catenin, Ki-67, p53, laminin5gamma2, matrilysin and MUC...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151667
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Serrated adenoma (SA) consists of glands both with intraluminal projection of tall columnar cells, which resemble the terminally differentiated cells in the surface epithelium, and with concave short cells, which resemble progenitor crypt cells of the colon. The aim of this study was to clarify the relationsh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151359
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Standard therapy for postoperative pain after laparoscopic colorectal surgeries at the Tan Tock Seng Hospital consists of intravenous morphine via patient-controlled analgesia (PCA) for the first 24-48 h, followed by oral analgesics. We compared the efficacy and safety of oral controlled-release (CR) oxycodo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000143221
更新日期:2008-01-01 00:00:00
abstract::Cancer pain management had received relatively little attention until the late 1990s, when approximately 100,000 new cancer cases and 60,000 cancer deaths occurred each year in Korea. In 2001, a Cancer Pain Management Guideline was prepared for the first time by the Korean Society of Hospice and Palliative Care. This ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000143211
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). PATIENTS AND METHODS:We analyzed TrkB expression in 161 GC patients by immunohistochemist...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151615
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To determine the dose-limiting toxicities (DLTs) and the maximum-tolerated doses of the paclitaxel, oxaliplatin (LOHP) and capecitabine combination in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received escalating doses of paclitaxel (starting dose 100 mg/m2) and LOHP (starting dose 40 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000111088
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Adenocarcinoma is the most frequent pathological type of stomach cancer. Hodgkin's lymphoma is a lymphoproliferative disease arising from lymphoid tissue which is characterized by Reed-Sternberg cells. Synchronous occurrence of these two malignancies has not been reported in the English literature so far. C...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000136799
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Osteosarcoma is a rare malignancy, and patients with this disease benefit from adjuvant chemotherapy. While cisplatin, anthracyclines and ifosfamide are the most commonly used agents in the treatment of osteosarcoma, a search for the best combination with higher efficacy and minimal toxicity continues. We pl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000113017
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the antitumor, survival, and adverse effects of hepatic arterial infusion chemotherapy using epirubicin in patients with advanced hepatocellular carcinoma and portal vein tumor thrombosis. METHODS:The study population comprised 45 consecutive patients with advanced...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000112805
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To examine the efficacy and prognostic benefits of radiotherapy (RT) in patients who have unresectable advanced hepatocellular carcinoma (HCC) with invasion to intrahepatic large vessels (IHLVs). METHODS:Sixty-eight patients who had advanced HCC with invasion to IHLVs were studied. Thirty-two consecutive pa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000120996
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111131
更新日期:2007-01-01 00:00:00
abstract::2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant food-derived mutagenic/carcinogenic heterocyclic amine (HCA), has attracted particular attention as a probable human colon carcinogen. Some studies have shown that PhIP administered in the post-initiation phase is able to enhance rat colon carci...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000127423
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The RUNX proteins are a family of transcriptional factors that have essential functions during embryogenesis and development, whereas deregulation in expression of RUNXs is often linked to tumor formation. To date, there has been no study describing the precise expression, prognostic impact and methylation s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000135350
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Gemcitabine monotherapy is the cornerstone of the treatment of patients suffering from advanced pancreatic cancer (PC). For a few years, new chemotherapeutic agents and combinations have been under validation. The use of such treatment makes it necessary to determine factors that could predict survival time....
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000120627
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Suboptimal debulking (>1 cm residual tumor) results in poor survival rates for patients with an advanced stage of ovarian cancer. The purpose of this study was to develop a prediction model, based on simple preoperative parameters, for patients with an advanced stage of ovarian cancer who are at risk of subo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000113051
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The role of Interleukin-2 (IL-2)-based biochemotherapy (BCT) for patients with metastatic melanoma remains controversial and few data of patients treated outside a specialized trial setting are available. METHODS:Sixty-six consecutive patients treated with BCT for stage IV melanoma were analyzed retrospecti...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000120029
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Since its introduction by Morton in 1992, sentinel lymph node (SLN) biopsy has become a standard procedure in the staging and treatment of primary melanoma and clinically negative regional lymph nodes. The primary aims of this procedure are to ascertain the individual lymphatic drainage patterns of primary t...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000136795
更新日期:2007-01-01 00:00:00
abstract::Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000127384
更新日期:2007-01-01 00:00:00
abstract:AIMS:We investigated the relationship between serum leptin concentrations and polymorphism of the leptin receptor gene and breast cancer. METHODS:Serum leptin concentrations were measured by enzyme-linked immunosorbent assay in 47 women with invasive breast cancer compared with 41 age-matched controls without cancer. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111097
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is useful for differentiating benign from malignant lesions, evaluating tumor stage, monitoring the response to therapy and detecting tumor recurrence in a variety of malignancies. Nevertheless, its use in patients with hepatocellular carcinoma (H...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111715
更新日期:2007-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is characterized as a highly chemoresistant cancer with no effective systemic therapy. Despite surgical or locoregional therapies, prognosis remains poor because of high tumor recurrence or tumor progression, and currently there are no well-established effective adjuvant therapies. The m...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000111705
更新日期:2007-01-01 00:00:00
abstract:BACKGROUNDS AND AIMS:Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a phospholipid mediator and acts by binding to a specific G-protein-coupled receptor. Though various functions of PAF have been associated with tumor activities, the mechanism of PAF-PAF receptor signaling in the de...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000113149
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of percutaneous cementoplasty for painful bone metastasis from hepatocellular carcinoma (HCC). METHODS:Cementoplasty was performed for 22 metastatic bone tumors in 13 patients. All patients had intractable pain and were diagnosed as metastatic bone tumor from HCC. The ostyneedle was in...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000113040
更新日期:2007-01-01 00:00:00
abstract::In pancreatic cancer (PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy. This review focuses on the role of carbohydrate antigen 19-9 (CA 19-...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000094888
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers. METHODS:We conducted a retrospective study of consecutively treated 22 inoperable biliary tract cancer patients with gemcitabine (500-1,000 mg/m(2) on days 1, 8, 15 every 4 weeks) as f...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000098109
更新日期:2006-01-01 00:00:00